| Pair Name | Vitamin K3, Imatinib | ||
| Phytochemical Name | Vitamin K3 (PubChem CID: 4055 ) | ||
| Anticancer drug Name | Imatinib (PubChem CID: 123596 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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| Pair Name | Vitamin K3, Imatinib | |||
| Disease Info | [ICD-11: 2B33.2] | Chronic myeloid leukemia | Investigative | |
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| Result | The results demonstrate that menadione and imatinib combination therapy may be a promising approach to refractory CML. | |||
| No. | Title | Href |
|---|---|---|
| 1 | The potentiation of menadione on imatinib by downregulation of ABCB1 expression. Clin Exp Pharmacol Physiol. 2020 Jun;47(6):997-1004. doi: 10.1111/1440-1681.13293. | Click |
